History of the Department

Biochemistry as a complementary subject started at Sree Narayana College, Kollam in the academic year 1976-77.  In the initial years the department offered complementary course for Botany, Zoology under graduate students. As of now Sree Narayana College is among one of the two colleges in University of Kerala, where students have the option to take Biochemistry/Chemistry as complementary for Botany and Zoology. Later on, when  Biotechnology course was introduced in the college during 1998-99, the department offered complementary Biochemistry to Biotechnology students also. The department also offers one Year PG Diploma Course in Diagnostic Molecular Science, which is approved by UGC under National Skill Qualification Framework (NSQF).

The pioneer of the department was Prof. A. Suresh Babu.  He held important positions in  various academic bodies of University of Kerala. His period of service was from Oct 1976-Mar 2007

Programmes offered

  1. Complementary Biochemistry for B.Sc.Botany and B.Sc.Zoology
  2. Complementary Biochemistry for B.Sc.Botany and Biotechnology
  3. One Year PG Diploma Course in Diagnostic Molecular Science

About the Course

Biochemistry is the study of biological phenomena at the molecular level. Its aim is to understand the fundamental chemical principles that govern complex biological systems. The major focuses include the basics in Biophysical Chemistry, Biomolecules, Enzymes and Bioenergetics, Intermediary Metabolism for Botany and Zoology graduates, while for biotechnology students the major thrust areas include Physical aspects of Biochemistry, Biomolecules, Physiology, Nutrition and Metabolism

The primary objectives of the course are 1) to give students a solid foundation in biological chemistry 2) to develop analytical and critical-thinking skills that allow independent exploration of biological phenomena through the scientific method 3) to introduce students to modern methods of biochemical experimentation within the disciplines of biochemistry and molecular biology.

Scope 

As the biotechnology industry continues to grow and become an essential part of our socio-economic, scientific and industrial progress, jobs will be available through a variety of sectors, since biochemistry is an integral part of Biotechnology. Fields requiring skills in biochemistry include, but are not limited to, bio pharmaceutics, bioinformatics, toxicology, pharmacokinetics, functional genomics, environmental monitoring, industrial safety, DNA vaccines, bio-remediation, high throughput chemistry, and other related fields. Having good skills in any of these areas can put students in a position sought in various sectors.

Mission

Department is committed to create a genuine interest among students in studying and pursuing research   in the field of Biochemistry.  

Vision

To create a platform for Biochemistry research in Sree Narayana College especially in the field of drug development as the faculties have the expertise in this area.

Activities

We conduct seminar/workshop /orientation programs/extension activities on current relevant topics ensuring complete participation of our students.

Dr Vinod B.S Assistant Professor

    Dr Ambili S HoD/Assistant Professor

    Peer reviewed Journals

    1. Chitosan Encapsulation Enhances the Bioavailability and Tissue Retention of Curcumin and Improves its Efficacy in Preventing B[a]P-induced Lung Carcinogenesis. Vinod Vijayakurup, Arun Kumar T Thulasidasan, Mohan Shankar G, Archana.P Retnakumari, C Devika Nandan, Jannet Somaraj, Jayesh Antony, Vijai V Alex, Vinod Balachandran, Vijayasteltar Liju, Sankar Sundaram, Vinod Kumar G S, and Ruby Anto. Cancer Prevention Research 2019 Apr;12(4):225-236, IF- 4.021, ISSN: 1940-6207.
    2. Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras. Minakshi Saikia, Archana P Retnakumari, Shabna Anwar, Nikhil P Anto, Rashmi Mittal, Shabna Shah, Kavya S Pillai, Balachandran S Vinod, Vidya Peter, Reeba Thomas and Ruby John Anto. Oncotarget. 2018; 9:18115-18127. IF- 5.168, ISSN: 1949-2553
    3. Sensitized Luminescence from novel pyrazolone based β-diketonate complexes of Eu3+, D. B. Ambili Raj, S. V. Manoj, and B.S. Vinod, Bulletin of Pure & Applied Sciences- Section C, 2018,37: 64-69, ISSN 2320 320X
    4. Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2–Akt axis. Balachandran S Vinod, H H Nair, V Vijayakurup, A Shabna, S Shah, A Krishna, K S Pillai, S Thankachan & R J Anto. Cell Death Discovery 1, (2015) ​doi:10.1038/cddiscovery.2015.61, ISSN 2058-7716
    5. Phytochemicals as Chemosensitizers: From Molecular Mechanism to Clinical Significance. Balachandran S Vinod, T T Maliekal and R J Anto. Antioxid Redox Signal. 2013 Apr 10; 18(11):1307-48. doi: 10.1089/ars.2012.4573. IF- 7.407
    6. Mechanistic evaluation of the signaling events regulating curcumin-mediatedchemosensitization of breast cancer cells to 5-fluorouracil. Balachandran S Vinod, Jayesh Antony, Haritha H.Nair, Vineshkumar T Puliyappadamba, Minakshi Saikia, Sai Shyam Narayanan, Arathy Bevin and Ruby John Anto. Cell Death Dis. 2013 Feb 21; 4: e505. doi: 10.1038/cddis.2013.26.ISSN-2041-4889 IF- 5.99
    7. Curcumin sensitizes breast cancer cells to 5-FU through thymidylate synthase- dependent downregulation of NF-κB. Haritha H Nair, Balachandran S Vinod, Jayesh Antony, Minakshi Saikia, Ruby John Anto, Journal of Carcinogenesis 01/2012; Vol.11(Supplement 1): pp-S31
    8. Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its downregulation by curcumin is independent. Vineshkumar T P, Vino T Cheriyan, Smitha V Bava, Arun Kumar T Thulasidas, Balachandran S Vinod, Priya R Prabhu, Ranji Varghese, Arathy Bevin, Shalini Venugopal and Ruby John Anto. Mol Cancer. 2010 Aug 20; 9:220. doi: 10.1186/1476-4598-9-220.IF- 3.779
    9. ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch dependent neural progenitors. Rajendran Sanalkumar, Chandrasekharan Lalitha Indulekha, Thulasi Sheela Divya, Mundackal Sivaraman Divya, Ruby John Anto, Balachandran S Vinod, SasidharanVidyanand, Balusamy Jagatha, Shalini Venugopal, Jackson James, J Neurochem. 2010 May; 113(4):807-18. IF-4.337
    10. Studies on the anti-hyperlipidemic Properties of Averrhoa bilimbi fruit in rats. Ambili S, A and Nagarajan. N.S. Planta Med. 2009; 75: 55-58.
    11. Hypolipidemic, antioxidant and cytotoxic properties of Benincasa hispida fruit juice. Ambili S, Anilkumar S and Subramoniam A. Biomedicine 2007;27(2):72-76.
    12. Human Epidermal Growth Factor Receptor signaling as a therapeutic target in breast cancer. Balachandran S Vinod and Ruby John Anto, Amala Research Bulletin 2006, 26, 18-27.
    13. Prevention and treatment of hyperlipidemia with neutraceuticals and herbal drugs in: Medicinal plants: Ethno-botanical Approach. Ambili S and Subramoniam. A. Agrobios (India), Jodpur (2006) pg.(319-345). ISBN: 81-7754-253-2

     

    Conference proceedings

     

    1. Involvement of Mitogen activated protein kinases in the activation of AP-1 in 5-FU treated breast cancer cells. BS Vinod, DB Ambiliraj, SV.Manoj & Ruby J Anto (2018), Proceedings of the National Seminar on New Horizons in Cancer Treatment and Prevention: From Bench to Bedside (Pg. No:68-71) organized by Department of Chemistry & Biochemistry, SN College, Kollam, sponsored by DST (SERB) & KSCSTE held from 16th to 17th March 2018 held at SN College, Kollam, ISBN 978-93-5300-765-2
    2. Evaluation of the Chemosensitizing efficacy of Curcumin in 5-Fu chemotherapy against breast cancer. Swetha. M, Haritha H Nair, Liju V B, Aiswarya U.S, S Vinod and Ruby John Anto, Proceedings of the National Seminar on New Horizons in Cancer Treatment and Prevention: From Bench to Bedside organized by Department of Chemistry & Biochemistry, SN College, Kollam, sponsored by DST (SERB) & KSCSTE held from 16th to 17th March 2018 held at SN College, Kollam, ISBN 978-93-5300-765-2
    3. Chemosensitization as a strategy to overcome chemoresistance and side effects of Docetaxel; an Invitro study. BS Vinod, Haritha H Nair, V Vinod, A Shabna, S Shabna & Ruby J Anto (2017) National seminar on recent trends in advanced chemistry research (RTACR-2017) organized by Dept. Of Chemistry on 25th and 26th may 2017 sponsored by DST (SERB) & KSCSTE at Sree Narayana College, Kollam. ISBN 978-93-5268-873-9
    4. HER-2-Akt signaling axis regulates the efficacy of resveratrol in chemosensitizing HER-2-over-expressing breast cancer cells to docetaxel. Haritha H Nair, BS Vinod, V Vinod, Aiswarya U.S, Vijai V.Alex, Nesteena K.N, Ruby John Anto, at International Conference on Nutraceuticals and Chronic Diseases sponsored by Society for Nutraceuticals and Chronic diseases & IIT, Guwahati, Assam on September 1st – 3rd 2017

     

     

     

     

     

     

    Research

    1. Pharmacological evaluation of Hemidesmus indicus root (extract/active fraction) for its utility as a phytomedicine to improve efficacy of ORS.
    2. Studies on the mechanism of action and pharmacological profile of the active fraction of Trichopus zeylanicus leaf towards developing the same as a standardized anti-stress/adaptogenic herbal drug (phytomedicine).
    3. Minor-UGC funded- Studies on the antioxidant properties of Averrhoa bilimbi Linn fruits MRP(S)-246/12-12/KLKE006/UGC-SWRO, Dated 29/3/13
    4. Evaluation of anticancer activity of Hemigraphis colorata, KSCSTE, Student project (2018-2019)
    5. Antimicrobial and anticancer activity of Ceratopteris thalictroids (L) brouguiart (2018-2019)
    6. Studies on the chemical components and antioxidant properties of Ceratopteris thalictroids (L) brouguiart KSCSTE, Student project (2017-2018)

    ‪Vinod Balachandran‬ – ‪Google Scholar‬

    Scopus preview – Balachandran, Vinod – Author details – Scopus

    1. NPTEL E-Awareness Workshop for Students & Mentors in association with IQAC and NPTEL SNC Kollam Local Chapter on 02/01/2021
    2. Webinar on “Basics of Biomedical Nanotechnology” in association with IQAC on 10/10/2020
    3. NPTEL Online Courses & Certification in association with IQAC and NPTEL SNC Kollam Local Chapter on 14/08/2020
    4. Webinar on “Role of phytochemicals in COVID-19 management” in association with IQAC, SN College, Kollam on 29/07/2020.
    5. Awareness webinar on COVID19 entitled “Corona Virus Disease-2019: All You Need to Know’’ in association with IQAC, SN College, Kollam on 23/07/20.
    6. One day Seminar on “Drug discovery from Natural Sources: “Recent Trends and Advances” organized as part of the Multidisciplinary Annual Seminar Series AGORA-2020 on 24/02/2020
    7. Planting of 50 tree saplings in the campus of SN College, Kollam in association with NSS unit with the help of State Medicinal plants board on 10/12/2019
    8. Interdepartmental Quiz Contest on General Awareness ‘INSIGHTS 2K19’ at Sree Narayana College, Kollam. 06/12/2019 funded by PTA
    9. One day workshop on “Basic Bioinformatics Tools and Techniques” in collaboration with PTA Sree Narayana College, Kollam on 29/10/2019
    10. One day seminar on “Life style and Chronic Diseases” on 13/02/2019 at SN College, Kollam. Funded by PTA
    11. Quiz competition “INQUISITIVE 2018” on 08/11/2018 at, Sree Narayana College, Kollam, funded by PTA.
    12. New Horizons in Cancer Treatment and Prevention: From Bench to Bedside sponsored by DST (SERB) and Kerala State Council for Science Technology and Environment (KSCSTE) on 16/03/2018 to 17/03/2018 at Sree Narayana College, Kollam.
    13. Intercollegiate Quiz Contest ‘Maieutic – 2018’ on General Awareness 12/03/2018    at S N College, Kollam, funded by PTA
    14. World ozone day celebrations 2017 sponsored by Kerala State Council for Science Technology and Environment (KSCSTE) on 20/09/2017 & 22/09/2017 at Sree Narayana College, Kollam.
    15. Wetland Day Celebration February 01-03, 2017 funded by Kerala State Council for Science, Technology and Environment (KSCSTE), Thiruvananthapuram.
    16. “Solid waste management and development of homestead garden” Sree Narayana College, Kollam, 26/10/2016.